Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2)

TECPR2 is a 1,411 amino acid protein that belongs to the WD repeat KIAA0329 family. TECPR2 contains three WD repeats, six TECPR repeats, and is encoded by a gene that maps to human chromosome 14q32.31. The WD40-repeat protein ATG16L1 and TECPR1 also associated with theCCT chaperonin complex implicated in the folding of WD40 proteins10. Chromosome 14 houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer"""s disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.