Testis Enhanced Gene Transcript (TEGT)

TEGT in the rat and humans does not belong to any known gene family of vertebrates. The deduced amino acid sequence of the gene and a bacterial protein of unknown function show low but significant homology and very similar hydrophobicity profiles. The 2 different transcripts are due to alternative usage of 2 polyadenylation sites. The presence of a nuclear targeting motif indicates that the gene product must localize to the nucleus.BI1 is an evolutionarily conserved integral membrane protein containing 6 predicted membrane-spanning segments and is predominantly localized to intracellular membranes, similar to BCL2 family proteins. The predicted protein contains 237 amino acids and is identical to TEGT.