Tetra Peptide Repeat Homeobox Protein 1 (TPRX1)

Homeobox genes, such as TPRX1, are characterized by the presence of a conserved DNA sequence, the homeobox, which encodes a DNA-binding domain, the homeodomain.Using PRD-class homeodomains to query a genome database, Booth and Holland (2007) identified TPRX1. The deduced protein contains 58 repeated copies of a 4-amino acid motif (variants of pro-ile-pro-gly) C-terminal to the homeodomain. EST database analysis indicated that TPRX1 is expressed in testis, eye, and brain.Booth and Holland (2007) determined that the TPRX1 gene contains 2 exons and spans over 2.4 kb.By genomic sequence analysis, Booth and Holland (2007) mapped the TPRX1 gene to chromosome 19q13.32. They identified a duplicate TPRX copy, that is likely a pseudogene, 35.1 kb away and on the other side of the CRX gene.