Tetratricopeptide Repeat Domain Protein 12 (TTC12)

Using genomic database analysis of human chromosome 11q23, a region commonly deleted in a variety of cancers, Katoh and Katoh (2003) identified TTC12, which they called TPARM. The 705-amino acid protein is predicted to be cytoplasmic, contains a tetratricopeptide repeat domain and 3 armadillo repeat domains, and shares 75.4% identity with mouse Ttc12. Analysis of EST databases showed TTC12 expression in testis, prostate, lung, germinal center B cells, neuroblastoma, teratocarcinoma, colon cancer, and gastric cancer.Katoh and Katoh (2003) determined that the TTC12 gene contains 22 exons spanning approximately 52 kb.Using genomic sequence analysis, Katoh and Katoh (2003) mapped the TTC12 gene to chromosome 11q23.2.