Tetratricopeptide Repeat Domain Protein 4 (TTC4)

The 34-amino acid tetratricopeptide repeat (TPR) motif is found in a variety of proteins and may mediate protein-protein or protein-membrane interactions.By screening multiple cDNA libraries with ESTs from chromosome 1p31, a region in which loss of heterozygosity has been frequently observed in breast cancers, followed by 5-prime RACE, Su et al. (1999) obtained a cDNA encoding TTC4. The deduced 356-amino acid protein has only limited identity with TTC1 and TTC2, but all have coiled-coil domains, and TTC4 has 4 TPR motifs. Northern blot analysis revealed wide expression of a 2.0-kb TTC4 transcript, although levels were low in lung.TTC4 gene contains 10 exons and spans 28 kb.