Tigger Transposable Element Derived Protein 1 (TIGD1)

TIGD1 belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known.The deduced Tigger1 and Tigger2 products share 48% amino acid identity, and both are related to the Drosophila pogo transposase. Smit and Riggs (1996) identified several MERs within the genome that appeared to arise by Tigger duplication. Tigger1 was represented primarily by full-length elements, whereas most elements related to Tigger2 were partial copies or included an internal deletion