Tigger Transposable Element Derived Protein 6 (TIGD6)

TIGD6 belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. TIGD3, TIGD4, and TIGD6 seem most closely related to CENP-B (see below), and, like CENP-B, they are widely distributed and highly conserved in mammals.Within a given mammalian genome, TIGD6 is consistently the closest relative to CENP-B, with an average pairwise amino acid identity of 28%.Phylogenetic distance analysis based on synonymous sites with an application of an average neutral substitution rate of ;2.2
9 in mammals is indicative of a coalescence time congruent with a much earlier divergence of CENP-B, TIGD3, TIGD4, and TIGD6