Trafficking Protein Particle Complex 6B (TRAPPC6B)

TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport .Gwynn et al. (2006) identified mouse Trappc6b. Trappc6b contains 2 motifs conserved in TRAPPC6A and several yeast TRAPP subunits, including Trs33, the putative homolog of TRAPPC6A and TRAPPC6B.Kummel et al. (2005) determined the 1.7-angstrom crystal structure of human TPC6. TPC6 adopted an alpha-beta-plait topology and formed dimers. In spite of their low sequence similarity, the structure of TPC6 resembled that of BET3 (TRAPPC3), particularly at the dimerization interface.By immunoprecipitation and protein pull-down experiments, Kummel et al. (2005) found that TPC6 could heterodimerize with BET3.