Transcription Factor CP2 Like Protein 1 (TFCP2L1)

LBP9 shares 83% amino acid identity with the LBP1B isoform of UBP1. RT-PCR followed by Southern blot analysis detected prominent expression of LBP9 only in JEG-3 cells, with little to no expression in human HepG2, NCI-H295A, and HeLa cell lines, human adrenal tissue, and monkey COS-1 cells.The deduced protein shares 88% amino acid identity with human TFCP2L1. Ribonuclease protection experiments revealed highest Crtr1 expression in adult mouse kidney and stomach. Expression was intermediate in placenta, testis, and small intestine and low in lung, mesenteric lymph nodes, muscle, ovary, and thymus. Crtr1 expression was not detected in brain, heart, liver, and spleen. In situ hybridization of embryonic and adult kidney showed Crtr1 expression restricted to the distal convoluted tubules.