Transcription Factor Dp2 (TFDP2)

Zhang and Chellappan (1995) cloned an E2F dimerization partner, transcription factor DP2, from a human kidney cDNA library. The TFDP2 gene encodes a predicted 386-amino acid protein that is 68% identical to TFDP1. Northern blot analysis revealed 5 distinct transcript sizes ranging from 1.4 to 9.5 kb, with expression of at least one size observed in all cell lines tested. TFDP2 is able to form a functional heterodimer with E2F1.Zhang et al. (1997) used fluorescence in situ hybridization to map the TFDP2 gene to human chromosome 3q23.High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.