Transcription factor 19 (TCF19)

Ku et al. (1991) cloned a growth-regulated cDNA by differential screening of a mouse 3T3 cell line library to identify transcripts induced by serum stimulation. Transcripts of the gene, designated SC1, were detectable beginning at about 8 hours after stimulation. The mouse cDNA was used to clone the human SC1 cDNA. The 2.6-kb cDNA encoded a deduced 359-amino acid polypeptide with features characteristic of transactivating factors. The gene was mapped by in situ hybridization to chromosome 6p21-p22. The bacterially expressed protein had the predicted size of 39 kD.Krishnan et al. (1995) mapped TCF19 with POU5F1 to a 0.2-Mb region between HLA-C and the so-called S gene at 6p21.3. POU5F1 and TCF19 are about 130 kb telomeric of HLAC and about 600 bp from each other.