Transcription factor 23 (TCF23)

Narumi et al. (2000) identified a novel mouse basic helix-loop-helix (bHLH) factor, Tcf23, which is expressed predominantly in the reproductive organs such as the uterus and ovary.Using in silico methods, Tachibana et al. (2001) identified the human ortholog of mouse Tcf23.Narumi et al. (2000) found that the mouse Tcf23 protein has an inhibitory activity similar to those of Id proteins  that are negative regulators of bHLH factors.Tachibana et al. (2001) determined that both the human and mouse TCF23 genes contain 3 exons.By genomic sequence analysis, Tachibana et al. (2001) mapped the TCF23 gene to chromosome 2p24-p23. By FISH, they mapped the mouse Tcf23 gene to the A3 region of chromosome 5.