Transducin Like Enhancer Of Split 6 (TLE6)

TLE6 shares significant similarity with the Drosophila groucho protein, particularly in the C-terminal WD40 repeat region. Northern blot analysis showed that Grg6 was expressed predominantly in heart, lung, liver, muscle, and testis, with very low expression in brain, spleen, and kidney.Although the transcripts encoding these proteins were degraded during meiotic maturation and ovulation, the SCMC persisted in the early embryo. The SCMC, which was located in the subcortex of the egg, was excluded from regions of cell-cell contact in the cleavage-stage embryo and segregated to the outer cells of the morulae and blastocyst. Oocytes lacking Floped and/or Mater were fertilized, but the embryos did not progress beyond the cleavage stage of development, and female mice lacking Floped and/or Mater were sterile.