Transforming, Acidic Coiled-Coil Containing Protein 2 (TACC2)

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. TACC2 concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.By searching an EST database with TACC1 as the probe, Still et al. (1999) identified cDNAs encoding TACC2 and TACC3. The coiled-coil region of the 652-amino acid TACC2 protein is highly related to that of TACC1, suggesting that TACC2 arose through gene duplication