Transient Receptor Potential Cation Channel Subfamily M, Member 3 (TRPM3)

TRPM3 belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified. TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in hepatocytes. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.TRPM3 expression in the cytoplasm of collecting tubular epithelium. Immunofluorescence and confocal microscopy showed that HA-tagged full-length TRPM3 localizes to the plasmalemmal compartment.