Transmembrane Channel Like Protein 8 (TMC8)

TMC8 is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.Computational analysis of the EV1 interval on the Human Genome Draft Sequence allowed construction of a contig of partially sequenced overlapping BACs. The EVER2 gene encodes 2 alternatively spliced proteins of 726 and 503 amino acids. EVER2 was predicted to contain 8 transmembrane domains and 3 leucine zipper motifs. EVER2 and EVER1 share approximately 28% amino acid identity, are expressed in the cytoplasm, and colocalize with calnexin, an integral membrane protein located in the endoplasmic reticulum.