Transmembrane Emp24 Protein Transport Domain Containing Protein 4 (TMED4)

Matsuda et al. (2003) cloned TMED4, which they called clone-156, from a human lung fibroblast cDNA library. The deduced protein contains 107 amino acids.Matsuda et al. (2003) found that TMED4 induced NF-kappa-B signaling 7-fold following expression in human embryonic kidney cells.By genomic sequence analysis, Matsuda et al. (2003) mapped the TMED4 gene to chromosome 7p22.2.NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products.