Transmembrane Protein 1 (TMEM1)

TMEM1 is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. This gene mapped less than 45 kb centromeric of D21S25 and spanned at least 56 kb of genomic DNA. Northern blot analysis revealed that 8-, 7.5-, and 5.3-kb transcripts are ubiquitously expressed in adult tissues. DNA sequence analysis showed a complete coding sequence of 3,570 bp with multiple putative transmembrane domains that shared partial homology with transmembrane proteins including sodium channel proteins.