Transmembrane Protein 14C (TMEM14C)

TMEM14C, a small transmembrane protein, and SLC25A39 and SLC22A4,members of the solute carrier family. TMEM14C, a short mitochondrial transmembrane protein (112 amino acids). This gene is found only in vertebrate animals; it exhibits strong expression in zebrafish ICM and appears essential for functional heme biosynthesis in erythrocytes, making this a strong candidate for further studies. Proteins detected by multidimensional protein identification technology in the cofractionating organelles were subtracted from the NE data set. In addition to all 13 known NE integral proteins, 67 uncharacterized open reading frames with predicted membrane-spanning regions were identified. All of the eight proteins tested targeted to the NE, indicating that there are substantially more integral proteins of the NE than previously thought.