Transmembrane Protein 154 (TMEM154)

TMEM154 regulation by known inflammatory mediators suggests that it heavily influences monocyte maturation and inflammatory response regulation. Since inflammation diseases are important contributors to the morbidity in AI/AN communities, particularly children, furthering knowledge of this gene will lead to insights and identification of new therapy targets. TMEM154 controls the monocyte movement, the first cells to enter the joints of children with poly JIA. TMEM154 is blunted in neonatal immune responses and increased in children with poly JIA.TMEM154 appeared more selectively regulated during IL-4-induced differentiation of monocytes than IFNg. TMEM154 mRNA expressed a pattern distinctly different from undifferentiated cells, TMEM154 was up regulated in THP-1 cells differentiated into macrophages.