Transmembrane Protein 165 (TMEM165)

TMEM165, Belongs to the UPF0016 (TC 9.B.26) family.The Clock gene encodes a basic helix-loop-helix (bHLH)-PAS transcription factor that regulates circadian rhythms in mice.This region contains the complete loci for the Clock and Tpardl (pFT27) genes, as well as the 3""" partial locus of the Neuromedin U gene; sequence analysis also suggests the presence of two previously unidentified genes.  Finally, a new BAC transgenic line indicates that the genomic region that is sufficient for rescue of the Clock mutant phenotype is no greater than 120 kb and tightly flanks the 3""" end of the Clock gene.