Transmembrane Protein 187 (TMEM187)

Faranda et al. (1996) identified a gene about 2 kb downstream from HCFC1, the host cell factor C1 gene located on Xq28. They identified the gene, which they called ITBA1, by using an approach that coupled genomic sequencing and EST database searching. Because the sequences came from CpG islands in the proximity of HCFC1 and GDX, ITBA1 was known to be located in the interval between L1CAM and G6PD . The gene has an open reading frame encoding 261 amino acids and is ubiquitously expressed.Nomenclature: Faranda (1996) stated that the designation of the ITBA gene was arbitrarily chosen from the acronym of the institute where she works, Istituto di Tecnologie Biomediche Avanzate, in Milan, Italy.