Transmembrane Protein 19 (TMEM19)

The hippocampus is involved in many neurological processes as well as disorders. Alternatively, more than 2 genes could modulate hippocampal size, and quantitative trait analysis may not be computationally powerful enough to identify the epistatic interactions that are occurring. Data correlation to microarray and phenotype databases revealed that hippocampal volume correlated to Protein Kinase C (PKC) activity and spatial orientation as measured by the Morris water maze.Tmem19, a highly expressed gene transcript, revealed a strong cis-QTL on chromosome 10, suggesting that it is not only modulating its own expression, but may modulate and be the transcription factor for other genes that control hippocampal size and function.