Transmembrane Protein 30B (TMEM30B)

By searching databases for homologs of yeast Cdc50 family proteins, which are involved in polarized cell division, Katoh and Katoh (2004) identified 3 human CDC50 genes, including TMEM30B, which they called CDC50B. The predicted CDC50B protein contains 351 amino acids. The human and yeast CDC50 proteins all have 2 transmembrane domains and an extracellular loop with 3 cysteines and an N-glycosylation site. In silico expression analysis revealed that CDC50B was expressed in pancreatic islet, kidney, and prostate, as well as in lung carcinoid, parathyroid tumor, bladder tumor, meningioma, and pancreatic cancer.By genomic sequence analysis, Katoh and Katoh (2004) mapped the TMEM30B gene to chromosome 14q23.1.