Transmembrane Protein 30C (TMEM30C)

TMEM30C transcripts were truncated due to mutations in splicing or poly(A) signals relative to the macaque gene, which encodes 2 splice variants derived from 7 or 8 exons that produce proteins with 1 or 2 transmembrane domains, respectively. In contrast, the major human transcript originates from 3 exons and lacks a stop codon, suggesting it does not produce a functional protein. A minor human transcript transcribed from 2 exons encodes a predicted 113-amino acid protein with 1 transmembrane domain. RT-PCR showed that TMEM30C was expressed exclusively in testis of human, macaque, and mouse. Expression of exons 5 through 8 in human and exons 6 through 8 in chimpanzee was not detected, suggesting that the 2-transmembrane form of TMEM30C is dispensable in hominoids.