Transmembrane Protein 87B (TMEM87B)

TMEM87B, a novel binding protein interacting with the HPV18 E6 oncoprotein and to perform an initial bioinformatics analysis. The TMEM87B gene structure, genomic localization, physical and chemical characteristics, subcellular localization and functional domain were predicted, as well as the systematic evolution analysis on similar proteins among several species. In the yeast two-hybrid assay, The special TMEM87B mRNA expression was detected in Hela cells and the blue clones were validated by the yeast mating assay. TMEM87B is a secretary protein, containing many phosphorylation sites and functional motifs and possibly involved in signal transduction and transcriptional control in carcinogenesis. The novel gene TMEM87B may interact with HPV18 E6 and may be a potential oncogenesis target according to the bioinformatics analysis.