Transmembrane Protein 98 (TMEM98)

TMEM98 codes a small transmembrane protein of unknown function, while SPACA3 codes an intra-acrosomal sperm protein mainly expressed in human spermatozoa and probably participating in the process of sperm-egg fusion during fertilization. Finally, ACCN1 encodes the Mammalian Degenerin protein, a proton-gated channel permeable to sodium, lithium and potassium. The function of these channels is to generate ionic currents involved in the transmission of the nervous signal. While it cannot be excluded that MYO1D, TMEM98 or SPACA3 are involved in MS pathogenesis, ACCN1 immediately appeared to be the only strong MS susceptibility candidate gene in the region explored.