Triggering Receptor Expressed On Myeloid Cells Like Protein 3 (TREML3)

TREML3 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties.all genes in the TREM cluster have an exon encoding the 5-prime UTR and leader peptide, a second exon encoding the IgV domain, and a variable number of downstream exons encoding the stalk, transmembrane, and cytoplasmic regions. TLT3 contains 5 exons. Unlike other members of the TREM cluster, the stalk region of TLT3 is split across 2 exons.The 165-amino acid protein has a calculated molecular mass of 18 kD. It contains an IgV domain, a transmembrane domain with a charged lys residue, and a cytoplasmic domain.