Triggering Receptor Expressed On Myeloid Cells Like Protein 4 (TREML4)

Triggering receptor expressed on myeloid cells (TREM) family of proteins are cell surface receptors that may be involved in the innate and adaptive immune response. TREML1 may play a significant role in maintaining vascular hemostasis, coagulation and inflammation at sites of injury through its location in platelets. Defects in the gene encoding TREML1 may be the cause of the Gray platelet syndrome, a rare inherited congenital bleeding disorder caused by a reduction or absence of the platelet α-granules in blood platelets. TREML4 (triggering receptor expressed on myeloid cells-like 4), also known as TLT4, is a 200 amino acid secreted protein containing one Ig-like V-type (immunoglobulin-like) domain. Predominantly expressed in spleen, TREML4 is suggested to be involved in recognizing dead cells by different types of phagocytes in spleen.