Tripartite Motif Containing Protein 14 (TRIM14)

TRIM proteins are composed of 3 zinc-binding domains, a RING, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. They are involved in development and cell growth.The deduced 406-amino acid protein is 25% identical to RFP. Northern blot analysis revealed wide expression of KIAA0129 that was highest in liver but undetectable in skeletal muscle.Northern blot analysis revealed ubiquitous expression of a 5.0-kb TRIM14 transcript. Fluorescence microscopy demonstrated expression in cytoplasmic speckles. Confocal microscopy failed to identify a subcellular localization. Interaction mating analysis indicated that TRIM14 does not form a homodimer.