Tripartite Motif Containing Protein 17 (TRIM17)

TRIM17 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene.The deduced proteins of both species contain 477 amino acids and share 74% overall sequence identity. Neither protein contains a signal peptide sequence or a transmembrane region, suggesting that RNF16 is an intracellular protein. RNF16 contains RING finger, B-box, and coiled-coil domains. Northern blot analysis revealed expression of a 2-kb transcript exclusively in testis in rat and human.