Tripartite Motif Containing Protein 22 (TRIM22)

TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon.The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon"""s antiviral effects. Sequence analysis predicted that the 442-amino acid protein is 44% and 41% identical to mouse Rpt1 and human SSA/RO52 (SSA1), respectively. It contains a ring finger, an intermediate motif, and a CHC3H2 zinc finger in its N terminus, as well as a central bipartite nuclear localization signal. TRIM22 may be involved in the transduction of IFN antiviral action.