Tripartite Motif Containing Protein 39 (TRIM39)

TRIM39 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms.The deduced 519-amino acid protein, 98% identical to the 489-amino acid mouse sequence, contains a RING finger B-box coiled-coil (RBCC) domain and a C-terminal B30.2 domain. Northern blot analysis revealed near ubiquitous expression of a 3.4-kb transcript, with strongest expression in testis.