Tripartite Motif Containing Protein 55 (TRIM55)

TRIM55 associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres.RNF29 shares 62% and 65% sequence identity with RNF28 and RNF30, respectively. All 3 proteins share a conserved N-terminal RING domain and zinc-binding B-box motif as well as 2 coiled-coil dimerization motif boxes in their central regions. In vitro, they form dimers/heterodimers by shared coiled-coil motifs. Dot-blot analysis demonstrated muscle-specific expression of RNF28 and RNF30, but low-level expression of RNF29 in liver in addition to expression in striated muscle. RNF29 expression is most abundant in the fetal heart and appears to be downregulated during cardiac development.