Tripartite Motif Containing Protein 67 (TRIM67)

TRIM proteins are composed of 3 zinc-binding domains, a RING, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. They are involved in development and cell growth.By searching for sequences encoding RBCC (N-terminal RING finger/B-box/coiled-coil) proteins, Short and Cox (2006) identified TRIM67, which they called TNL.The deduced protein contains an N-terminal RING finger domain, 2 B-boxes, a coiled-coil region, a COS box, an FN3 domain, and a B30.2 domain. TRIM67 shares 65% amino acid identity with TRIM9.Short and Cox (2006) determined that the TRIM67 gene contains 12 exons and spans about 53 kb.