Tripartite Motif Containing Protein 7 (TRIM7)

TRIM7 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. GNIP1 encodes the longest deduced protein, with 511 amino acids and a calculated molecular mass of 56.6 kD. The N-terminal 206 amino acids of GNIP1 are identical to those of TRIM7, but GNIP1 extends to include a C-terminal B30.2-like domain. GNIP2 encodes a truncated 303-amino acid protein that lacks all of the N-terminal domains of GNIP1 and has only the B30.2-like domain. GNIP3 is a 329-amino acid protein that differs from the other GNIP proteins at the N terminus, but it has the C-terminal B30.2 domain.