Tripartite Motif Containing Protein 74 (TRIM74)

By searching EST databases for sequences near the region of chromosome 7 deleted in Williams-Beuren syndrome (WBS), Micale et al. (2008) identified and cloned TRIM74. The deduced 250-amino acid protein contains a RING finger domain, a B-box type-2 domain, and a coiled-coil region. TRIM74 is 94% identical to the N-terminal 250 amino acids of TRIM50 and 99.6% identical to TRIM73.Micale et al. (2008) determined that the TRIM74 gene contains 5 exons.By genomic sequence analysis, Micale et al. (2008) mapped the TRIM74 gene to chromosome 7q11.23, centromeric to the interval deleted in WBS.Micale et al. (2008) determined that the TRIM73 and TRIM74 genes resulted from duplication of a region of chromosome 7q11.23 containing the TRIM50 gene. The mouse genome contains Trim50, but it lacks Trim73 and Trim74 due to an absence of the Trim50 duplication.