Tripartite Motif Family Like Protein 2 (TRIML2)

TRIML2 Contains 1 B30.2/SPRY domain. The B30.2/SPRY domain is present in 700 eukaryotic (150 human) proteins, including medically important proteins such as TRIM5 and Pyrin. Nonetheless, the functional role of this modular domain remained unclear. One end of the -sandwich as the surface interacting with an RNA helicase VASA with a 40 nM dissociation constant. The sequence variation in TRIM5 responsible for HIV-1 restriction and most of the mutations in Pyrin causing familial Mediterranean fever map on this surface, implicating the corresponding region in many B30.2/SPRY domains as the ligand-binding site. The amino acids lining the binding surface are highly variable among the B30.2/SPRY domains, suggesting that these domains are protein-interacting modules, which recognize a specific individual partner protein rather than a consensus sequence motif.