Tudor And KH Domain Containing Protein (TDRKH)

The variants differ in their 3-prime ends due to alternative splicing or use of alternative polyadenylation signals. No TDRKH variant shows similarity to ICLN, but an intronic sequence of TDRKH appears to contain an ICLN pseudogene. The longest deduced TDRKH protein contains 606 amino acids and has 2 KH domains and 1 tudor domain. TDRKH splice variants encode shorter proteins that contain only the first KH domain, both KH domains without the tudor domain, or only the first KH domain with the tudor domain. Northern blot analysis detected major TDRKH transcripts of about 4.0 and 2.8 kb and minor transcripts of about 4.8, 2.3, and 1.8 kb. Expression was highest in brain and heart, intermediate in kidney, lung, and small intestine, and low in muscle.