Two Pore Segment Channel 1 (TPCN1)

Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6.The deduced 775-amino acid protein, which may be N-terminally truncated, contains motifs associated with ion transport proteins. RT-PCR ELISA detected robust expression in all adult and fetal tissues and specific brain regions examined. Highest expression was in heart and kidney, and lowest expression was in spleen.The deduced 819-amino acid protein has a calculated molecular mass of 94.6 kD. It contains 2 homologous domains, each of which has 6 transmembrane segments (S1 to S6) and a putative pore loop between S5 and S6.