U3 Small Nucleolar Ribonucleoprotein 3, Homolog (UTP3)

The deduced 469-amino acid protein is rich in charged amino acids and contains a putative leucine zipper region and a region that shares significant homology with yeast Sas10. In situ hybridization revealed expression in olfactory bulb and cerebral cortex in mouse embryos at 17.5 days postcoitum. Postnatally, Crl1 expression was also observed in cerebellar cortex, with strong expression in hippocampus.The stage-specific expression of IgJ and Crlz1 was regulated by chromatin accessibility and acetylation. DNase I hypersensitive site 1 on the IgJ promoter was opened in plasma cells, but hypersensitive sites 9 and 10 on the Crlz1 promoter were opened in pre-B cells. H3 and H4 histones were hyperacetylated in the chromatin of Crlz1 in pre-B cells, whereas those in the chromatin of IgJ were hyperacetylated in plasma cells.