Ubiquitin Domain Containing Protein 2 (UBTD2)

The deduced 106-amino acid DCUBP protein has a calculated molecular mass of 12.2 kD. Its UBQ domain shares 28.6% identity with that of ubiquitin; however, it does not possess the C-terminal Gly-Gly that is required for ubiquitination, suggesting that it may not be involved in protein degradation. Immunolocalization indicated that DCUBP localizes to cytoplasm, especially in the mitochondrion. However, the DCUBP transcript was enriched in multiple tumor cell lines, including A431, MCF7, Lovo, HT29, PC-3, SMMC7721, and U251. DCUBP expression was significantly decreased in tumor necrosis-related apoptosis-inducing ligand (TRAIL)- and all-trans retinoid acid agonist (ATRA)-stimulated HL60 cells. DCUBP may be involved in TRAIL-induced apoptosis or retinoid acid receptor-alpha signaling processes.