V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2)

VSIG2 gene contains 7 conserved exons, with each Ig domain encoded by 2 half-domain exons with unusual splicing junctions.The deduced 325-amino acid CTH protein, which is 29% similar to GPA33, contains a signal peptide, an extracellular V-type Ig-like domain followed by a C2-type Ig-like domain, a transmembrane region devoid of charged residues, and a cytoplasmic tail. There are multiple N-glycosylation sites in the extracellular region and phosphorylation sites in the cytoplasmic tail. Northern blot analysis revealed CTH expression in stomach, colon, prostate, trachea, and thyroid gland, with lower levels in bladder and lung. CTH expression was not detected in thymus, although CTH could be amplified by PCR from a thymus cDNA library. The Ctx-like molecules are novel members of the Ig superfamily