Vacuolar Protein Sorting 26A (VPS26A)

VPS26A belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. The deduced 327-amino acid protein was predicted to be a soluble protein. Northern blot analysis of multiple human tissues revealed ubiquitous expression of a single transcript of about 3 kb.