Visual System Homeobox Protein 2 (VSX2)

HOX10 encodes a developmentally regulated homeobox originally identified by De Chen et al. (1989) on the basis of its relatively abundant, retina-specific expression. Liu et al. (1994) cloned a mouse Chx10 cDNA.Percin et al. (2000) cloned a human CHX10 cDNA encoding a deduced 361-amino acid polypeptide with 97% overall identity to mouse Chx10 and complete identity in the homeodomain and CVC domain. In situ hybridization to human fetal retinal sections detected CHX10 expression in retinal neuroblasts at all stages examined. Human CHX10 is expressed in progenitor cells of the developing neuroretina and in the inner nuclear layer of the mature retina.