Von Willebrand Factor A Domain Containing Protein 7A (vWA7A)

Albertella et al. (1996) probed the intergenic region adjacent to G7A (VARS). Exon trapping succeeded in identifying 2 exons comprising 232 bp of G7C. Using sequence analysis, Snoek et al. (2000) showed that an 85% identical gene is located in the syntenic region of the mouse MHC. The mouse G7c cDNA totals 4.3 kb and encodes an 891-amino acid protein. RT-PCR analysis revealed low level expression in all mouse tissues tested. The human cDNA identified by Albertella et al. (1996) and the nucleotide sequence of mouse exons 6 through 16 are 82% identical, and their predicted proteins are 76% identical and 81% similar over 536 amino acids. Snoek et al. (2000) noted that the G7c gene harbors a recombinatorial hotspot within the mouse class III region.