Von Willebrand Factor D and EGF Domain Containing Protein (vWDE)

VWDE Contains 7 EGF-like domains.Contains 1 VWFD domain. The VWFC domain is named after the von Willebrand factor (VWF) type C repeat which is found twice in this multidomain protein. It has a length of about 70 amino acids covering 10 well conserved cysteines.  Human VWF, a multifunctional protein involved in maintaining homeostasis. It consists of 4 VWFD domains, 3 VWFA domains, 3 VWFB domains, 2 VWFC domains, an X domain and a C-terminal cystine knot. There might be a third VWFC domain within the type B domain region. the von Willebrand factor for which the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial dimerization step. The presence of this region in other complex-forming proteins leads to the assumption that the VWFC domain might be involved in forming larger protein complexes.