WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing Protein 2 (WFIKKN2)

WFIKKN2 encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. WFIKKN2 shares 57% identity with WFIKKN1 and the same domain structure, a WAP domain, a follistatin domain, an IgG domain, 2 Kunitz domains, and an NTR domain. EST database analysis identified WFIKKN2 expression in fetal brain. RT-PCR analysis of adult human tissues detected high expression in ovary and testis, moderate to low expression in pancreas, brain, and lung, and no expression in other tissues examined. In fetal tissues, WFIKKN2 was expressed in brain, skeletal muscle, thymus, and kidney.