WD Repeat Containing Domain Protein 16 (WDR16)
Английские синонимы
WDRPUH; CFAP52; WD40-Repeat Protein Upregulated In HCC; Cilia-and flagella-associated protein 52
WD repeat-containing proteins, such as WDR16, play crucial roles in a wide range of physiologic functions, including signal transduction, RNA processing, remodeling the cytoskeleton, regulation of vesicular traffic, and cell division.WDR16 contains 11 WD40 repeat domains and shares 84 to 89% amino acid identity with the mouse, rat, and monkey Wdr16 proteins. Northern blot analysis of 16 human tissues detected a 2.2-kb WDR16 transcript only in testis. Immunofluorescence localization detected WDR16 in the cytoplasm of transfected human cell lines.RT-PCR showed that WDR16 was overexpressed in 8 of 10 additional HCC tissues. Small interfering RNA directed to WDR16 significantly reduced WDR16 expression in HCC cells and resulted in growth suppression.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
