WD Repeat Containing Domain Protein 35 (WDR35)

WDR35 is WD40 domain-containing protein. Studies in mouse and several lower organisms have implicated WDR35 in intraflagellar transport. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The deduced 1,170-amino acid protein contains 4 N-terminal WD40 domains and shares 92.7% identity with human WDR35. Quantitative RT-PCR detected Wdr35 expression in all rat tissues examined, with highest expression in testis, followed by brain, and lowest expression in spleen.